Genotoxic evaluation of drugs and any chemical compound or mixtures being considered for clinical applications must be performed accordingly to international institutions such as FDA, IARC and EPA 15. The genotoxic effects of many plant extracts and EOs in humans cannot be underestimated, despite its natural origin 22, 23, 24, 25, 26, 27, 28. Nonetheless, the biological activities of EOs from C. maxima, have also shown antibiotic and antimycotic activities 14, 15, 16, 17, 18, 19, 20, 21. Essential oils (EOs) from Citrus species like C. In this regard, several studies have shown antioxidant properties derived from flavonoids, carotenoids and vitamin C, which are present at high concentrations in the Citrus genus 10, 11, 12, 13. Throughout human history there has been increasing interest in natural alternative medicine and nowadays, active principles of medical plants are the focus of scientific papers 9. albicans and the growing evidence of antifungal resistance, leads necessarily to seek for new therapeutic alternatives 5, 6, 7, 8. The incoming infection with most Candida species, other than C. OC is also common on pediatric and elderly patients 2, 3, 4. These infections have been described as a secondary complication in several diseases and it frequently sprouts in immunosuppressed patients that underwent high exposition to antibiotics and corticosteroids. Oral candidiasis (OC) is a mucosal illness caused by infection of Candida species, mainly by Candida albicans ( C. These properties might bestow different odontological applications to each essential oil. Flow cytometry was used to measure toxicity in human oral epithelial cells, C. Genotoxic evaluation was done by Ames test where none of the oils induced point mutations. sinensis were in a range of 0.42–3.71 μg and for C. The minimum inhibitory concentrations (MIC) for C. guilliermondii with IC50 of 6.90 and 2.92 μg respectively. latifolia essential oil was effective to inhibit growing of C. Antifungal properties were studied by agar diffusion method, where C. sinensis, d-limonene (96%) and α-myrcene (2.79%) and in C. The major components determined by GC-MS were in C. latifolia were obtained from the peel by hydro-distillation.

latifolia) against five Candida species: Candida albicans, Candida tropicalis, Candida glabrata, Candida lusitaniae and Candida guilliermondii and perform its genotoxic evaluation. The aim of this study was to evaluate the antifungal activity of essential oils (EOs) of Citrus sinensis ( C.

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